|
rs429358
|
|
C |
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project.
|
31473137 |
2019 |
|
rs748703149
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a whole-exome sequencing study of a family with probable AD-type dementia without pathogenic variants in known autosomal dominant dementia disease genes and negative for the apolipoprotein E (APOE) ε4 allele, we identified an extremely rare TREM2 coding variant, that is, a glycine-to-tryptophan substitution at amino acid position 145 (NM_018965.3:c.433G>T/p.[Gly145Trp]).
|
31464095 |
2020 |
|
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among ε4/ε4 individuals, AD risk</span> increased substantially in a dose-dependent manner with the number of <i>APOE</i> promoter SNP rs405509 <i>T</i> alleles in EastAs <i>(TT</i>: OR (odds ratio) = 27.02, <i>p</i> = 8.80 × 10<sup>-94</sup>; <i>GT</i>: OR = 15.87, <i>p</i> = 2.62 × 10<sup>-9</sup>) and EuroAs (<i>TT</i>: OR = 18.13, <i>p</i> = 2.69 × 10<sup>-108</sup>; <i>GT</i>: OR = 12.63, <i>p</i> = 3.44 × 10<sup>-64</sup>), and rs405509-<i>T</i> homozygotes had a younger onset and more severe cortical atrophy than those with <i>G</i>-allele.
|
31426376 |
2019 |
|
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Education, sex, and the APOE-rs405509 variant are associated with Alzheimer's disease and cognitive performance.
|
31100889 |
2019 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
GWASCAT |
Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension.
|
31055733 |
2019 |
|
rs405509
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs7259620
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs7412
|
|
C |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs769449
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs769450
|
|
G |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs7412
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs1081105
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs769452
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We tested if the ε4 major isoform of the APOE gene and rs405509 and rs440446 promoter and intron-1 polymorphisms predicted risk of any dementia or Alzheimer's disease with diagnoses derived from the Hospital Discharge and Causes of Death Registers in 1453 participants of the Helsinki Birth Cohort Study.
|
30293724 |
2019 |
|
rs440446
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested if the ε4 major isoform of the APOE gene and rs405509 and rs440446 promoter and intron-1 polymorphisms predicted risk of any dementia or Alzheimer's disease with diagnoses derived from the Hospital Discharge and Causes of Death Registers in 1453 participants of the Helsinki Birth Cohort Study.
|
30293724 |
2019 |
|
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the presented study, we investigated the association between -491 A/T (rs449647), -427C/T, (rs769446) and -219 T/G (rs405509) single nucleotide polymorphisms (SNPs) of APOE gene and AD risk in the Polish population.
|
29990559 |
2018 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
BEFREE |
In the presented study, we investigated the association between -491 A/T (rs449647), -427C/T, (rs769446) and -219 T/G (rs405509) single nucleotide polymorphisms (SNPs) of APOE gene and AD risk in the Polish population.
|
29990559 |
2018 |
|
rs449647
|
|
|
0.730 |
GeneticVariation |
BEFREE |
In the presented study, we investigated the association between -491 A/T (rs449647), -427C/T, (rs769446) and -219 T/G (rs405509) single nucleotide polymorphisms (SNPs) of APOE gene and AD risk in the Polish population.
|
29990559 |
2018 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs449647
|
|
|
0.730 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs7412
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs1081105
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease.
|
29776682 |
2018 |
|
rs7412
|
|
|
0.720 |
GeneticVariation |
BEFREE |
APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease.
|
29776682 |
2018 |